Eye Anatomy and Disorders

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Articles January 2022

Diagnosis of Choroidal Disease With Deep Learning-Based Image Enhancement and Volumetric Quantification of Optical Coherence Tomography

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Kazuichi Maruyama; Song Mei; Hirokazu Sakaguchi; Chikako Hara; Atsuya Miki; Zaixing Mao; Ryo Kawasaki; Zhenguo Wang; Susumu Sakimoto; Noriyasu Hashida; Andrew J. Quantock; Kinpui Chan; Kohji Nishida
TAGS: central serous chorioretinopathy, choroid diseases, eye, image enhancement, learning, optical coherence tomography, pathology, volume, choroid, vasculature
Trans. Vis. Sci. Tech.. 2022; 11(1):22. doi: https://doi.org/10.1167/tvst.11.1.22

Includes: Multimedia, Supplemental Content

Articles January 2022

Progression of cRORA (Complete RPE and Outer Retinal Atrophy) in Dry Age-Related Macular Degeneration Measured Using SD-OCT

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Or Shmueli; Roei Yehuda; Adi Szeskin; Leo Joskowicz; Jaime Levy
TAGS: age-related macular degeneration, follow-up, retinal atrophy, spectral domain-optical coherence tomography, atrophy, eye
Trans. Vis. Sci. Tech.. 2022; 11(1):19. doi: https://doi.org/10.1167/tvst.11.1.19

Clinical and Epidemiologic Research January 2022

Local Geographic Atrophy Growth Rates Not Influenced by Close Proximity to Non-Exudative Type 1 Macular Neovascularization

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Omer Trivizki; Eric M. Moult; Liang Wang; Prashanth Iyer; Yingying Shi; Giovanni Gregori; William Feuer; James G. Fujimoto; Philip J. Rosenfeld
TAGS: atrophy, growth rate, neovascularization, pathologic
Invest. Ophthalmol. Vis. Sci.. 2022; 63(1):20. doi: https://doi.org/10.1167/iovs.63.1.20

Glaucoma January 2022

In Vivo Sublayer Analysis of Human Retinal Inner Plexiform Layer Obtained by Visible-Light Optical Coherence Tomography

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Zeinab Ghassabi; Roman V. Kuranov; Joel S. Schuman; Ronald Zambrano; Mengfei Wu; Mengling Liu; Behnam Tayebi; Yuanbo Wang; Ian Rubinoff; Xiaorong Liu; Gadi Wollstein; Hao F. Zhang; Hiroshi Ishikawa
TAGS: eye, glaucoma, optical coherence tomography, vaccine information sheets, visible light, diagnostic imaging
Invest. Ophthalmol. Vis. Sci.. 2022; 63(1):18. doi: https://doi.org/10.1167/iovs.63.1.18

Includes: Supplemental Content

Articles January 2022

Corneal Confocal Microscopy in Type 1 Diabetes Mellitus: A Six-Year Longitudinal Study

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Stuti L. Misra; James A. Slater; Charles N. J. McGhee; Monika Pradhan; Geoffrey D. Braatvedt
TAGS: cornea, diabetes mellitus, type 1, longitudinal studies, microscopy, confocal, neurons, neuropathy, hemoglobin a, glycosylated
Trans. Vis. Sci. Tech.. 2022; 11(1):17. doi: https://doi.org/10.1167/tvst.11.1.17

Articles January 2022

Perspectives on Implementing the Patient Health Questionnaire-4 in Low-Vision Service Organizations to Screen for Depression and Anxiety

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Ellen B. M. Elsman; Edine P. J. van Munster; Femke van Nassau; Peter Verstraten; Ruth M. A. van Nispen; Hilde P. A. van der Aa
TAGS: anxiety, depression screening, depressive disorders, health, health personnel, questionnaires, visual impairment, mental health
Trans. Vis. Sci. Tech.. 2022; 11(1):16. doi: https://doi.org/10.1167/tvst.11.1.16

Includes: Supplemental Content

Articles January 2022

A Robust Microbead Occlusion Model of Glaucoma for the Common Marmoset

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Sandeep Kumar; Alexandria Benavente-Perez; Reynolds Ablordeppey; Carol Lin; Suresh Viswanathan; Abram Akopian; Stewart A. Bloomfield
TAGS: callithrix, glaucoma, injections, intraocular pressure, microspheres, eye
Trans. Vis. Sci. Tech.. 2022; 11(1):14. doi: https://doi.org/10.1167/tvst.11.1.14

Retina January 2022

Ultra-Widefield Indocyanine Green Angiography Reveals Patterns of Choroidal Venous Insufficiency Influencing Pachychoroid Disease

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Tommaso Bacci; Daniel J. Oh; Michael Singer; SriniVas Sadda; K. Bailey Freund
TAGS: blood outflow, discharge, body substance, drainage procedure, eye, indocyanine green angiography, venous anastomosis, venous insufficiency, choroid
Invest. Ophthalmol. Vis. Sci.. 2022; 63(1):17. doi: https://doi.org/10.1167/iovs.63.1.17

Includes: Supplemental Content

Articles January 2022

Comparison of ETDRS 7-Field to 4-Widefield Digital Imaging in the Evaluation of Diabetic Retinopathy Severity

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Barbara A. Blodi; Amitha Domalpally; Ashley H. Tjaden; Nancy Barrett; Emily Y. Chew; William C. Knowler; Christine G. Lee; Xavier Pi-Sunyer; Amisha Wallia; Neil H. White; Marinella Temprosa
TAGS: diabetic retinopathy, diagnostic imaging, eye
Trans. Vis. Sci. Tech.. 2022; 11(1):13. doi: https://doi.org/10.1167/tvst.11.1.13

Includes: Supplemental Content

Articles January 2022

Malondialdehyde-Modified Photoreceptor Outer Segments Promote Choroidal Neovascularization in Mice

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Yuhong Chen; Xinyue Zhu; Fuxiang Ye; Hong Wang; Xiaoling Wan; Ting Zhang; Yuwei Wang; Yimin Wang; Xiaohuan Zhao; Xinyue Bai; Yushu Xiao; Xiaodong Sun
TAGS: choroidal neovascularization, malondialdehyde, mice, photoreceptors, retinal pigment cell, cell culture techniques, vascular endothelial growth factor a, injections
Trans. Vis. Sci. Tech.. 2022; 11(1):12. doi: https://doi.org/10.1167/tvst.11.1.12

Includes: Supplemental Content

Articles January 2022

Learning to Discover Explainable Clinical Features With Minimum Supervision

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Lutfiah Al Turk; Darina Georgieva; Hassan Alsawadi; Su Wang; Paul Krause; Hend Alsawadi; Abdulrahman Zaid Alshamrani; George M. Saleh; Hongying Lilian Tang
TAGS: datasets, learning, signs and symptoms, transfer technique, professional supervision
Trans. Vis. Sci. Tech.. 2022; 11(1):11. doi: https://doi.org/10.1167/tvst.11.1.11

Glaucoma January 2022

Matrix Mechanotransduction via Yes-Associated Protein in Human Lamina Cribrosa Cells in Glaucoma

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Rory Murphy; Mustapha Irnaten; Alan Hopkins; Jeffrey O'Callaghan; W. Daniel Stamer; Abbot F. Clark; Deborah Wallace; Colm J. O'Brien
TAGS: glaucoma, proteins, verteporfin, cribriform plate, mechanotransduction, cellular
Invest. Ophthalmol. Vis. Sci.. 2022; 63(1):16. doi: https://doi.org/10.1167/iovs.63.1.16

Articles January 2022

Tubercular Uveitis in Uveitis Cases in a High TB and HIV Setting: A Prospective Cohort Study

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Hassan D. Alli; Naseer Ally; Ismail Mayet; Lavania Joseph; Shaheed V. Omar; Shabir A. Madhi
TAGS: prospective studies, tuberculosis and hiv, tuberculous uveitis, uveitis, tuberculosis
Trans. Vis. Sci. Tech.. 2022; 11(1):9. doi: https://doi.org/10.1167/tvst.11.1.9

Retinal Cell Biology January 2022

PKA and Epac1 Reduce Nek7 to Block the NLRP3 Inflammasome Proteins in the Retinal Vasculature

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Li Liu; Youde Jiang; Jena J. Steinle
TAGS: inflammasomes, nlr family, pyrin domain-containing 3 protein, proteins, mice, dna, complementary, retinal vasculature
Invest. Ophthalmol. Vis. Sci.. 2022; 63(1):14. doi: https://doi.org/10.1167/iovs.63.1.14

Retina January 2022

Opticin Ameliorates Hypoxia-Induced Retinal Angiogenesis by Suppression of Integrin α2-I Domain–Collagen Complex Formation and RhoA/ROCK1 Signaling

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Xiaoxue Liu; Yue Xing; Xin Liu; Lingyan Zeng; Jin Ma
TAGS: collagen, hypoxia, integrins, retinal neovascularization, rhoa gtp-binding protein, zebrafish, angiogenesis, retina
Invest. Ophthalmol. Vis. Sci.. 2022; 63(1):13. doi: https://doi.org/10.1167/iovs.63.1.13

Includes: Supplemental Content

Clinical Trials January 2022

Exploratory Phase II Multicenter, Open-Label, Clinical Trial of ST266, a Novel Secretome for Treatment of Persistent Corneal Epithelial Defects

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Bennie H. Jeng; Pedram Hamrah; Ziv Z. Kirshner; Benjamin C. Mendez; Howard C. Wessel; Larry R. Brown; David L. Steed
TAGS: corneal epithelial defect, persistence, wound healing, eye, cornea, eyedrops, cytokine, safety
Trans. Vis. Sci. Tech.. 2022; 11(1):8. doi: https://doi.org/10.1167/tvst.11.1.8

Visual Neuroscience January 2022

Columnar and Laminar Segregation of Retinal Input to the Primate Superior Colliculus Revealed by Anterograde Tracer Injection Into Each Eye

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Mikayla D. Dilbeck; Zachary R. Spahr; Rakesh Nanjappa; John R. Economides; Jonathan C. Horton
TAGS: eye, injections, primates, superior colliculus, cercopithecidae
Invest. Ophthalmol. Vis. Sci.. 2022; 63(1):9. doi: https://doi.org/10.1167/iovs.63.1.9

Includes: Supplemental Content

Retina January 2022

Visual Field Characteristics in East Asian Patients With Occult Macular Dystrophy (Miyake Disease): EAOMD Report No. 3

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Seong Joon Ahn; Lizhu Yang; Kazushige Tsunoda; Mineo Kondo; Yu Fujinami-Yokokawa; Natsuko Nakamura; Takeshi Iwata; Min Seok Kim; Yongseok Mun; Jun Young Park; Kwangsic Joo; Kyu Hyung Park; Yozo Miyake; Ruifang Sui; Kaoru Fujinami; Se Joon Woo; for the East Asia Inherited Retinal Disease Society Study Group
TAGS: asian, macular dystrophy, scotoma, scotoma, central, visual fields, eye, phenotype, visual field testing, disclosure, genetics
Invest. Ophthalmol. Vis. Sci.. 2022; 63(1):12. doi: https://doi.org/10.1167/iovs.63.1.12

Includes: Supplemental Content

Immunology and Microbiology January 2022

Amoebicidal Activity of Poly-Epsilon-Lysine Functionalized Hydrogels

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Stephnie M. Kennedy; Pallavi Deshpande; Andrew G. Gallagher; Malcolm J. Horsburgh; Heather E. Allison; Stephen B. Kaye; Donald A. Wellings; Rachel L. Williams
TAGS: cysts, hydrogel, hydrogels, toxic effect, trophozoite, lysine, cornea
Invest. Ophthalmol. Vis. Sci.. 2022; 63(1):11. doi: https://doi.org/10.1167/iovs.63.1.11

Includes: Supplemental Content

Glaucoma January 2022

Longitudinal In Vivo Changes in Radial Peripapillary Capillaries and Optic Nerve Head Structure in Non-Human Primates With Early Experimental Glaucoma

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Gwen Musial; Suman Adhikari; Hanieh Mirhajianmoghadam; Hope M. Queener; Alexander W. Schill; Nimesh B. Patel; Jason Porter
TAGS: blood capillaries, diagnostic imaging, eye, glaucoma, optic disk, perfusion, primates, retinal nerve fiber layer, lasers, spectral domain-optical coherence tomography
Invest. Ophthalmol. Vis. Sci.. 2022; 63(1):10. doi: https://doi.org/10.1167/iovs.63.1.10

Includes: Supplemental Content

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Diagnosis of Choroidal Disease With Deep Learning-Based Image Enhancement and Volumetric Quantification of Optical Coherence Tomography

Progression of cRORA (Complete RPE and Outer Retinal Atrophy) in Dry Age-Related Macular Degeneration Measured Using SD-OCT

Local Geographic Atrophy Growth Rates Not Influenced by Close Proximity to Non-Exudative Type 1 Macular Neovascularization

In Vivo Sublayer Analysis of Human Retinal Inner Plexiform Layer Obtained by Visible-Light Optical Coherence Tomography

Corneal Confocal Microscopy in Type 1 Diabetes Mellitus: A Six-Year Longitudinal Study

Perspectives on Implementing the Patient Health Questionnaire-4 in Low-Vision Service Organizations to Screen for Depression and Anxiety

A Robust Microbead Occlusion Model of Glaucoma for the Common Marmoset

Ultra-Widefield Indocyanine Green Angiography Reveals Patterns of Choroidal Venous Insufficiency Influencing Pachychoroid Disease

Comparison of ETDRS 7-Field to 4-Widefield Digital Imaging in the Evaluation of Diabetic Retinopathy Severity

Malondialdehyde-Modified Photoreceptor Outer Segments Promote Choroidal Neovascularization in Mice

Learning to Discover Explainable Clinical Features With Minimum Supervision

Matrix Mechanotransduction via Yes-Associated Protein in Human Lamina Cribrosa Cells in Glaucoma

Tubercular Uveitis in Uveitis Cases in a High TB and HIV Setting: A Prospective Cohort Study

PKA and Epac1 Reduce Nek7 to Block the NLRP3 Inflammasome Proteins in the Retinal Vasculature

Opticin Ameliorates Hypoxia-Induced Retinal Angiogenesis by Suppression of Integrin α2-I Domain–Collagen Complex Formation and RhoA/ROCK1 Signaling

Exploratory Phase II Multicenter, Open-Label, Clinical Trial of ST266, a Novel Secretome for Treatment of Persistent Corneal Epithelial Defects

Columnar and Laminar Segregation of Retinal Input to the Primate Superior Colliculus Revealed by Anterograde Tracer Injection Into Each Eye

Visual Field Characteristics in East Asian Patients With Occult Macular Dystrophy (Miyake Disease): EAOMD Report No. 3

Amoebicidal Activity of Poly-Epsilon-Lysine Functionalized Hydrogels

Longitudinal In Vivo Changes in Radial Peripapillary Capillaries and Optic Nerve Head Structure in Non-Human Primates With Early Experimental Glaucoma

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