Nanotechnology and Regenerative Medicine

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Articles May 2022

Delivery of Hydrophobic Drugs to the Posterior Ocular Region by Gel-in-Water Nanoemulsion

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Jannatul Fardous; Yuuta Inoue; Kozue Yoshida; Fumiyasu Ono; Akihiro Higuchi; Hiroyuki Ijima
TAGS: biocompatibility, drug delivery systems, gel, hydrophobicity, nanogels, particle size, permeability, water, sterilization, sexual, chemical surfactants
Trans. Vis. Sci. Tech.. 2022; 11(5):16. doi: https://doi.org/10.1167/tvst.11.5.16

Includes: Supplemental Content

Articles May 2022

Ultrasound Targeted Microbubble Destruction Promotes the Therapeutic Effect of HUMSC Transplantation on Glaucoma-Caused Optic Nerve Injury in Rabbits

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Tianhui Zhu; Xiaosheng Huang; Shiming Peng; Ye Ye; Jun Zhao
TAGS: glaucoma, microbubbles, optic nerve injuries, oryctolagus cuniculus, transplantation, ultrasonography
Trans. Vis. Sci. Tech.. 2022; 11(5):12. doi: https://doi.org/10.1167/tvst.11.5.12

Articles May 2022

Posttransplant VEGFR1R2 Trap Eye Drops Inhibit Corneal (Lymph)angiogenesis and Improve Corneal Allograft Survival in Eyes at High Risk of Rejection

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Wei Zhang; Alfrun Schönberg; Felix Bock; Claus Cursiefen
TAGS: cd40 ligand, cornea, eye, eyedrops, keratoplasty, rejection (psychology), telomeric repeat amplification protocol, thyroid hormone associated protein complex, allografting, transplantation
Trans. Vis. Sci. Tech.. 2022; 11(5):6. doi: https://doi.org/10.1167/tvst.11.5.6

Includes: Supplemental Content

Retinal Cell Biology April 2022

Retinal Neuroprotective Effect of Mesenchymal Stem Cells Secretome Through Modulation of Oxidative Stress, Autophagy, and Programmed Cell Death

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Ricardo Usategui-Martín; Kevin Puertas-Neyra; Nadia Galindo-Cabello; Leticia A. Hernández-Rodríguez; Fernando González-Pérez; José Carlos Rodríguez-Cabello; Rogelio González-Sarmiento; José Carlos Pastor; Ivan Fernandez-Bueno
TAGS: apoptosis, autophagy, genes, necroptosis, nerve degeneration, neuroprotective effect, oxidative stress, proteins, rna, messenger, secretome
Invest. Ophthalmol. Vis. Sci.. 2022; 63(4):27. doi: https://doi.org/10.1167/iovs.63.4.27

Includes: Supplemental Content

Retinal Cell Biology April 2022

Identification of CD157-Positive Vascular Endothelial Stem Cells in Mouse Retinal and Choroidal Vessels: Fluorescence-Activated Cell Sorting Analysis

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Taku Wakabayashi; Hisamichi Naito; Tomohiro Iba; Kohji Nishida; Nobuyuki Takakura
TAGS: cell separation, choroid, endothelium, fluorescence, mice, retina, stem cells, electroconvulsive therapy, cd31 antigens, epidural cortical stimulation
Invest. Ophthalmol. Vis. Sci.. 2022; 63(4):5. doi: https://doi.org/10.1167/iovs.63.4.5

Includes: Supplemental Content

Cornea April 2022

Defining the Role of Mitochondrial Fission in Corneal Myofibroblast Differentiation

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Kye-Im Jeon; Ankita Kumar; Kaitlin T. Wozniak; Keith Nehrke; Krystel R. Huxlin
TAGS: cornea, fibroblasts, fibrosis, mitochondria, myofibroblasts, phosphorylation
Invest. Ophthalmol. Vis. Sci.. 2022; 63(4):2. doi: https://doi.org/10.1167/iovs.63.4.2

Includes: Supplemental Content

Retina March 2022

AAV8 -Mediated Gene Therapy Rescues Retinal Degeneration Phenotype in a Tlcd3b Knockout Mouse Model

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Xinye Qian; Hehe Liu; Shangyi Fu; Jiaxiong Lu; Yu-Ting Hung; Cassidy Turner; Haiwei Gu; Rui Chen
TAGS: gene therapy, mice, phenotype, photoreceptors, retinal degeneration, mice, knockout, retina, ceramides, tissue degeneration, injections
Invest. Ophthalmol. Vis. Sci.. 2022; 63(3):11. doi: https://doi.org/10.1167/iovs.63.3.11

Includes: Supplemental Content

Articles February 2022

Measurement Properties of the Attitudes to Gene Therapy for the Eye (AGT-Eye) Instrument for People With Inherited Retinal Diseases

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Myra B. McGuinness; Alexis Ceecee Britten-Jones; Lauren N. Ayton; Robert P. Finger; Fred K. Chen; John Grigg; Heather G. Mack
TAGS: attitude, eye, gene therapy, retinal diseases, perception
Trans. Vis. Sci. Tech.. 2022; 11(2):14. doi: https://doi.org/10.1167/tvst.11.2.14

Includes: Supplemental Content

Visual Neuroscience January 2022

Retinal Dopamine D2 Receptors Participate in the Development of Myopia in Mice

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Furong Huang; Ziheng Shu; Qin Huang; Kaijie Chen; Wenjun Yan; Wenjing Wu; Jinglei Yang; Qiongsi Wang; Fengjiao Wang; Chunlan Zhang; Jia Qu; Xiangtian Zhou
TAGS: mice, myopia, retina, dopamine d2 receptor, fibroblasts
Invest. Ophthalmol. Vis. Sci.. 2022; 63(1):24. doi: https://doi.org/10.1167/iovs.63.1.24

Includes: Supplemental Content

Articles December 2021

A Loop-mediated Isothermal Amplification With a Nanoparticle-Based Lateral Flow Biosensor Assay to Detect Pseudomonas aeruginosa in Endophthalmitis

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Kui Dong; ZhiMing Kang; Xuan Ji; Xinxin Zhang; PeiNi Cheng; Bin Sun
TAGS: amplification, endophthalmitis, lights, manufactured, bacterial endophthalmitis, fluid flow, pseudomonas aeruginosa, nanoparticles
Trans. Vis. Sci. Tech.. 2021; 10(14):26. doi: https://doi.org/10.1167/tvst.10.14.26

Anatomy and Pathology/Oncology November 2021

Carboplatin- and Etoposide-Loaded Lactoferrin Protein Nanoparticles for Targeting Cancer Stem Cells in Retinoblastoma In Vitro

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Revu V. L. Narayana; Pritikana Jana; Neha Tomar; Varsha Prabhu; Rohini M. Nair; Radhika Manukonda; Swathi Kaliki; Sarah E. Coupland; Jodi Alexander; Helen Kalirai; Anand K. Kondapi; Geeta K. Vemuganti
TAGS: cancer stem cells, carboplatin, culture media, conditioned, etoposide, lactoferrin, nanoparticles, proteins, retinoblastoma, drug release, cytotoxicity
Invest. Ophthalmol. Vis. Sci.. 2021; 62(14):13. doi: https://doi.org/10.1167/iovs.62.14.13

Includes: Supplemental Content

Editorial November 2021

The 2021 National Eye Institute Strategic Plan: Driving Innovation in Eye and Vision Research

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Michael F. Chiang
TAGS: eye, vision research
Invest. Ophthalmol. Vis. Sci.. 2021; 62(14):2. doi: https://doi.org/10.1167/iovs.62.14.2

Special Issue November 2021

Outer Retinal Cell Replacement: Putting the Pieces Together

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Allison L. Ludwig; David M. Gamm
TAGS: cell therapy, donors, transplantation, transfer technique, safety, retina, cell transplantation, animal model
Trans. Vis. Sci. Tech.. 2021; 10(10):15. doi: https://doi.org/10.1167/tvst.10.10.15

Includes: Supplemental Content

Retinal Cell Biology October 2021

Transplanted Mouse Embryonic Stem Cell–Derived Retinal Ganglion Cells Integrate and Form Synapses in a Retinal Ganglion Cell-Depleted Mouse Model

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You-Ren Wu; Tomoyo Hashiguchi; Junki Sho; Shih-Hwa Chiou; Masayo Takahashi; Michiko Mandai
TAGS: embryonic stem cells, mice, n-methylaspartate, retina, retinal ganglion cells, tissue transplants, transplantation, stem cells, synapses, neurites
Invest. Ophthalmol. Vis. Sci.. 2021; 62(13):26. doi: https://doi.org/10.1167/iovs.62.13.26

Includes: Supplemental Content

Articles October 2021

Metal Oxide Engineered Nanomaterials Modulate Rabbit Corneal Fibroblast to Myofibroblast Transformation

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Atsuhiko Fukuto; Soohyun Kim; Jennifer Kang; Brooke L. Gates; Maggie W. Chang; Kent E. Pinkerton; Laura S. Van Winkle; Yoshiaki Kiuchi; Christopher J. Murphy; Brian C. Leonard; Sara M. Thomasy
TAGS: cornea, fibroblasts, metals, myofibroblasts, nanostructures, oryctolagus cuniculus, oxides, proteins, cell survival, rna, messenger
Trans. Vis. Sci. Tech.. 2021; 10(12):23. doi: https://doi.org/10.1167/tvst.10.12.23

Includes: Supplemental Content

Articles October 2021

Region of Interest Densitometry Analysis of Descemet Membrane Endothelial Keratoplasty Dehiscence on Anterior Segment Optical Coherence Tomography

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Albert Y. Cheung; Andrew Kalina; Alex Im; Andrew R. Davis; Medi Eslani; Raymond L. Hogge; Elizabeth Yeu
TAGS: dehiscence, densitometry, descemet membrane endothelial keratoplasty, optical coherence tomography, cornea
Trans. Vis. Sci. Tech.. 2021; 10(12):6. doi: https://doi.org/10.1167/tvst.10.12.6

Retina September 2021

Oxidative Stress Resistance 1 Gene Therapy Retards Neurodegeneration in the rd1 Mutant Mouse Model of Retinopathy

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Bhubanananda Sahu; Laura Moreno Leon; Wei Zhang; Nikita Puranik; Ramesh Periasamy; Hemant Khanna; Michael Volkert
TAGS: gene therapy, injections, mice, nerve degeneration, oxidative stress, retinal degeneration, retinal diseases, photoreceptors, caspases, electroretinography
Invest. Ophthalmol. Vis. Sci.. 2021; 62(12):8. doi: https://doi.org/10.1167/iovs.62.12.8

Includes: Supplemental Content

Articles September 2021

Aqueous Cytokine Levels Are Associated With Progression of Peripheral Anterior Synechiae After Descemet Stripping Automated Endothelial Keratoplasty

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Yuki Kusano; Takefumi Yamaguchi; Sota Nishisako; Takehiro Matsumura; Masaki Fukui; Kazunari Higa; Toshihiro Inoue; Jun Shimazaki
TAGS: cytokine, descemet stripping endothelial keratoplasty, isolated tumor cells, peripheral anterior synechiae, protein measurement, total, eye
Trans. Vis. Sci. Tech.. 2021; 10(11):12. doi: https://doi.org/10.1167/tvst.10.11.12

Includes: Supplemental Content

Special Issue September 2021

In Vivo Subretinal ARPE-19 Cell Tracking Using Indocyanine Green Contrast-Enhanced Multimodality Photoacoustic Microscopy, Optical Coherence Tomography, and Fluorescence Imaging for Regenerative Medicine

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Van Phuc Nguyen; Yanxiu Li; Jessica Henry; Thomas Qian; Wei Zhang; Xueding Wang; Yannis M. Paulus
TAGS: diagnostic imaging, fluorescence, indocyanine green, injections, optical coherence tomography, cell tracking, regenerative medicine
Trans. Vis. Sci. Tech.. 2021; 10(10):10. doi: https://doi.org/10.1167/tvst.10.10.10

Special Issue August 2021

Transitioning into GMP-Compliance: Alternative Methods for Producing Retinal Organoids for Transplantation

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Hannah Cobb; Silvia Aparicio-Domingo; M. Valeria Canto-Soler
TAGS: cyclic gmp, good manufacturing practice, organoids, transplantation
Trans. Vis. Sci. Tech.. 2021; 10(10):9. doi: https://doi.org/10.1167/tvst.10.10.9

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Delivery of Hydrophobic Drugs to the Posterior Ocular Region by Gel-in-Water Nanoemulsion

Ultrasound Targeted Microbubble Destruction Promotes the Therapeutic Effect of HUMSC Transplantation on Glaucoma-Caused Optic Nerve Injury in Rabbits

Posttransplant VEGFR1R2 Trap Eye Drops Inhibit Corneal (Lymph)angiogenesis and Improve Corneal Allograft Survival in Eyes at High Risk of Rejection

Retinal Neuroprotective Effect of Mesenchymal Stem Cells Secretome Through Modulation of Oxidative Stress, Autophagy, and Programmed Cell Death

Identification of CD157-Positive Vascular Endothelial Stem Cells in Mouse Retinal and Choroidal Vessels: Fluorescence-Activated Cell Sorting Analysis

Defining the Role of Mitochondrial Fission in Corneal Myofibroblast Differentiation

AAV8 -Mediated Gene Therapy Rescues Retinal Degeneration Phenotype in a Tlcd3b Knockout Mouse Model

Measurement Properties of the Attitudes to Gene Therapy for the Eye (AGT-Eye) Instrument for People With Inherited Retinal Diseases

Retinal Dopamine D2 Receptors Participate in the Development of Myopia in Mice

A Loop-mediated Isothermal Amplification With a Nanoparticle-Based Lateral Flow Biosensor Assay to Detect Pseudomonas aeruginosa in Endophthalmitis

Carboplatin- and Etoposide-Loaded Lactoferrin Protein Nanoparticles for Targeting Cancer Stem Cells in Retinoblastoma In Vitro

The 2021 National Eye Institute Strategic Plan: Driving Innovation in Eye and Vision Research

Outer Retinal Cell Replacement: Putting the Pieces Together

Transplanted Mouse Embryonic Stem Cell–Derived Retinal Ganglion Cells Integrate and Form Synapses in a Retinal Ganglion Cell-Depleted Mouse Model

Metal Oxide Engineered Nanomaterials Modulate Rabbit Corneal Fibroblast to Myofibroblast Transformation

Region of Interest Densitometry Analysis of Descemet Membrane Endothelial Keratoplasty Dehiscence on Anterior Segment Optical Coherence Tomography

Oxidative Stress Resistance 1 Gene Therapy Retards Neurodegeneration in the rd1 Mutant Mouse Model of Retinopathy

Aqueous Cytokine Levels Are Associated With Progression of Peripheral Anterior Synechiae After Descemet Stripping Automated Endothelial Keratoplasty

In Vivo Subretinal ARPE-19 Cell Tracking Using Indocyanine Green Contrast-Enhanced Multimodality Photoacoustic Microscopy, Optical Coherence Tomography, and Fluorescence Imaging for Regenerative Medicine

Transitioning into GMP-Compliance: Alternative Methods for Producing Retinal Organoids for Transplantation

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