Nanotechnology and Regenerative Medicine

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Anatomy and Pathology/Oncology November 2021

Carboplatin- and Etoposide-Loaded Lactoferrin Protein Nanoparticles for Targeting Cancer Stem Cells in Retinoblastoma In Vitro

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Revu V. L. Narayana; Pritikana Jana; Neha Tomar; Varsha Prabhu; Rohini M. Nair; Radhika Manukonda; Swathi Kaliki; Sarah E. Coupland; Jodi Alexander; Helen Kalirai; Anand K. Kondapi; Geeta K. Vemuganti
TAGS: cancer stem cells, carboplatin, culture media, conditioned, etoposide, lactoferrin, nanoparticles, proteins, retinoblastoma, drug release, cytotoxicity
Invest. Ophthalmol. Vis. Sci.. 2021; 62(14):13. doi: https://doi.org/10.1167/iovs.62.14.13

Includes: Supplemental Content

Editorial November 2021

The 2021 National Eye Institute Strategic Plan: Driving Innovation in Eye and Vision Research

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Michael F. Chiang
TAGS: eye, vision research
Invest. Ophthalmol. Vis. Sci.. 2021; 62(14):2. doi: https://doi.org/10.1167/iovs.62.14.2

Special Issue November 2021

Outer Retinal Cell Replacement: Putting the Pieces Together

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Allison L. Ludwig; David M. Gamm
TAGS: cell therapy, donors, transplantation, transfer technique, safety, retina, cell transplantation, animal model
Trans. Vis. Sci. Tech.. 2021; 10(10):15. doi: https://doi.org/10.1167/tvst.10.10.15

Includes: Supplemental Content

Retinal Cell Biology October 2021

Transplanted Mouse Embryonic Stem Cell–Derived Retinal Ganglion Cells Integrate and Form Synapses in a Retinal Ganglion Cell-Depleted Mouse Model

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You-Ren Wu; Tomoyo Hashiguchi; Junki Sho; Shih-Hwa Chiou; Masayo Takahashi; Michiko Mandai
TAGS: embryonic stem cells, mice, n-methylaspartate, retina, retinal ganglion cells, tissue transplants, transplantation, stem cells, synapses, neurites
Invest. Ophthalmol. Vis. Sci.. 2021; 62(13):26. doi: https://doi.org/10.1167/iovs.62.13.26

Includes: Supplemental Content

Articles October 2021

Metal Oxide Engineered Nanomaterials Modulate Rabbit Corneal Fibroblast to Myofibroblast Transformation

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Atsuhiko Fukuto; Soohyun Kim; Jennifer Kang; Brooke L. Gates; Maggie W. Chang; Kent E. Pinkerton; Laura S. Van Winkle; Yoshiaki Kiuchi; Christopher J. Murphy; Brian C. Leonard; Sara M. Thomasy
TAGS: cornea, fibroblasts, metals, myofibroblasts, nanostructures, oryctolagus cuniculus, oxides, proteins, cell survival, rna, messenger
Trans. Vis. Sci. Tech.. 2021; 10(12):23. doi: https://doi.org/10.1167/tvst.10.12.23

Includes: Supplemental Content

Articles October 2021

Region of Interest Densitometry Analysis of Descemet Membrane Endothelial Keratoplasty Dehiscence on Anterior Segment Optical Coherence Tomography

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Albert Y. Cheung; Andrew Kalina; Alex Im; Andrew R. Davis; Medi Eslani; Raymond L. Hogge; Elizabeth Yeu
TAGS: dehiscence, densitometry, descemet membrane endothelial keratoplasty, optical coherence tomography, cornea
Trans. Vis. Sci. Tech.. 2021; 10(12):6. doi: https://doi.org/10.1167/tvst.10.12.6

Retina September 2021

Oxidative Stress Resistance 1 Gene Therapy Retards Neurodegeneration in the rd1 Mutant Mouse Model of Retinopathy

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Bhubanananda Sahu; Laura Moreno Leon; Wei Zhang; Nikita Puranik; Ramesh Periasamy; Hemant Khanna; Michael Volkert
TAGS: gene therapy, injections, mice, nerve degeneration, oxidative stress, retinal degeneration, retinal diseases, photoreceptors, caspases, electroretinography
Invest. Ophthalmol. Vis. Sci.. 2021; 62(12):8. doi: https://doi.org/10.1167/iovs.62.12.8

Includes: Supplemental Content

Articles September 2021

Aqueous Cytokine Levels Are Associated With Progression of Peripheral Anterior Synechiae After Descemet Stripping Automated Endothelial Keratoplasty

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Yuki Kusano; Takefumi Yamaguchi; Sota Nishisako; Takehiro Matsumura; Masaki Fukui; Kazunari Higa; Toshihiro Inoue; Jun Shimazaki
TAGS: cytokine, descemet stripping endothelial keratoplasty, isolated tumor cells, peripheral anterior synechiae, protein measurement, total, eye
Trans. Vis. Sci. Tech.. 2021; 10(11):12. doi: https://doi.org/10.1167/tvst.10.11.12

Includes: Supplemental Content

Special Issue September 2021

In Vivo Subretinal ARPE-19 Cell Tracking Using Indocyanine Green Contrast-Enhanced Multimodality Photoacoustic Microscopy, Optical Coherence Tomography, and Fluorescence Imaging for Regenerative Medicine

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Van Phuc Nguyen; Yanxiu Li; Jessica Henry; Thomas Qian; Wei Zhang; Xueding Wang; Yannis M. Paulus
TAGS: diagnostic imaging, fluorescence, indocyanine green, injections, optical coherence tomography, cell tracking, regenerative medicine
Trans. Vis. Sci. Tech.. 2021; 10(10):10. doi: https://doi.org/10.1167/tvst.10.10.10

Special Issue August 2021

Transitioning into GMP-Compliance: Alternative Methods for Producing Retinal Organoids for Transplantation

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Hannah Cobb; Silvia Aparicio-Domingo; M. Valeria Canto-Soler
TAGS: cyclic gmp, good manufacturing practice, organoids, transplantation
Trans. Vis. Sci. Tech.. 2021; 10(10):9. doi: https://doi.org/10.1167/tvst.10.10.9

Special Issue August 2021

Preclinical Evaluation of the Safety and Efficacy of Cryopreserved Bone Marrow Mesenchymal Stromal Cells for Corneal Repair

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Ilham Putra; Xiang Shen; Khandaker N. Anwar; Behnam Rabiee; Ravand Samaeekia; Enmar Almazyad; Pushpanjali Giri; Sayena Jabbehdari; Mohammed R. Hayat; Abdelrahman M. Elhusseiny; Mahmood Ghassemi; Nadim Mahmud; Deepak P. Edward; Charlotte E. Joslin; Mark I. Rosenblatt; Reza Dana; Medi Eslani; Peiman Hematti; Ali R. Djalilian
TAGS: bone marrow, cornea, cryopreservation, injections, safety, stem cell, mesenchymal, wound healing, eye, oryctolagus cuniculus
Trans. Vis. Sci. Tech.. 2021; 10(10):3. doi: https://doi.org/10.1167/tvst.10.10.3

Includes: Supplemental Content

Special Issue August 2021

The NEI Audacious Goals Initiative: Advancing the Frontier of Regenerative Medicine

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Steven M. Becker; Santa J. Tumminia; Michael F. Chiang
TAGS: regenerative medicine
Trans. Vis. Sci. Tech.. 2021; 10(10):2. doi: https://doi.org/10.1167/tvst.10.10.2

Articles August 2021

Retinal Protection by Sustained Nanoparticle Delivery of Oncostatin M and Ciliary Neurotrophic Factor Into Rodent Models of Retinal Degeneration

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Jing-Yan Yang; Bin Lu; Qiang Feng; Jorge S. Alfaro; Po-Hsuen Chen; Joseph Loscalzo; Wen-Bin Wei; Ying-Yi Zhang; Shi-Jiang Lu; Shaomei Wang
TAGS: ciliary neurotrophic factor, nerve growth factors, retinal degeneration, neuroprotection
Trans. Vis. Sci. Tech.. 2021; 10(9):6. doi: https://doi.org/10.1167/tvst.10.9.6

Retinal Cell Biology July 2021

Optic Nerve Engraftment of Neural Stem Cells

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Jiun L. Do; Salam Allahwerdy; Ryan Caezar C. David; Robert N. Weinreb; Mark H. Tuszynski; Derek S. Welsbie
TAGS: neural stem cells, optic nerve, axon
Invest. Ophthalmol. Vis. Sci.. 2021; 62(9):30. doi: https://doi.org/10.1167/iovs.62.9.30

Anatomy and Pathology/Oncology July 2021

Transcriptomic Profiling of Control and Thyroid-Associated Orbitopathy (TAO) Orbital Fat and TAO Orbital Fibroblasts Undergoing Adipogenesis

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Dong Won Kim; Kamil Taneja; Thanh Hoang; Clayton P. Santiago; Timothy J. McCulley; Shannath L. Merbs; Nicholas R. Mahoney; Seth Blackshaw; Fatemeh Rajaii
TAGS: adipocytes, fibroblasts, genes, orbital fat, rna-seq, small nuclear rna, thyroid
Invest. Ophthalmol. Vis. Sci.. 2021; 62(9):24. doi: https://doi.org/10.1167/iovs.62.9.24

Includes: Supplemental Content

Articles July 2021

Effect of Vitamin D3 on Regulating Human Tenon's Fibroblasts Activity

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Shuo Jia; Fushun Chen; Huogang Wang; Gandhervin Kesavamoorthy; Jimmy Shiu-Ming Lai; Ian Yat-Hing Wong; Kin Chiu; Jonathan Cheuk-Hung Chan
TAGS: cholecalciferol, fibroblasts, glaucoma, pterygium, vitamin d3 24-hydroxylase, rna-seq, cell survival
Trans. Vis. Sci. Tech.. 2021; 10(8):7. doi: https://doi.org/10.1167/tvst.10.8.7

Includes: Supplemental Content

Cornea June 2021

Ex Vivo–Induced Bone Marrow-Derived Myeloid Suppressor Cells Prevent Corneal Allograft Rejection in Mice

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Jun Zhu; Takenori Inomata; Keiichi Fujimoto; Koichiro Uchida; Kenta Fujio; Ken Nagino; Maria Miura; Naoko Negishi; Yuichi Okumura; Yasutsugu Akasaki; Kunihiko Hirosawa; Mizu Kuwahara; Atsuko Eguchi; Hurramhon Shokirova; Ai Yanagawa; Akie Midorikawa-Inomata; Akira Murakami
TAGS: cornea, keratoplasty, myeloid-derived suppressor cells, mice, rejection (psychology), transplant rejection
Invest. Ophthalmol. Vis. Sci.. 2021; 62(7):3. doi: https://doi.org/10.1167/iovs.62.7.3

Includes: Supplemental Content

Articles May 2021

Longitudinal Evaluation of Hyper-Reflective Foci in the Retina Following Subretinal Delivery of Adeno-Associated Virus in Non-Human Primates

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Eduardo Rodríguez-Bocanegra; Fabian Wozar; Immanuel P. Seitz; Felix F. L. Reichel; Alex Ochakovski; Kirsten Bucher; Barbara Wilhelm; K. Ulrich Bartz-Schmidt; Tobias Peters; M. Dominik Fischer; for the RD-CURE Consortium
TAGS: adeno-associated virus, eye, gene therapy, injections, primates, retina, spectral domain-optical coherence tomography, surgical procedures, operative, microglia
Trans. Vis. Sci. Tech.. 2021; 10(6):15. doi: https://doi.org/10.1167/tvst.10.6.15

Includes: Supplemental Content

Articles April 2021

Effect of CPAP Therapy on 24-Hour Intraocular Pressure-Related Pattern From Contact Lens Sensors in Obstructive Sleep Apnea Syndrome

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María Jesús Muniesa; Iván Benítez; Juan Ezpeleta; Manuel Sánchez de la Torre; Marta Pazos; Elena Millà; Ferrán Barbé
TAGS: contact lenses, continuous positive airway pressure, intraocular pressure, obstructive sleep apnea, sensor, night time
Trans. Vis. Sci. Tech.. 2021; 10(4):10. doi: https://doi.org/10.1167/tvst.10.4.10

Articles April 2021

Omidenepag, a Selective, Prostanoid EP2 Agonist, Does Not Suppress Adipogenesis in 3D Organoids of Human Orbital Fibroblasts

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Fumihito Hikage; Yosuke Ida; Yuika Ouchi; Megumi Watanabe; Hiroshi Ohguro
TAGS: agonists, fibroblasts, organoids, prostaglandins
Trans. Vis. Sci. Tech.. 2021; 10(4):6. doi: https://doi.org/10.1167/tvst.10.4.6

Includes: Supplemental Content

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Carboplatin- and Etoposide-Loaded Lactoferrin Protein Nanoparticles for Targeting Cancer Stem Cells in Retinoblastoma In Vitro

The 2021 National Eye Institute Strategic Plan: Driving Innovation in Eye and Vision Research

Outer Retinal Cell Replacement: Putting the Pieces Together

Transplanted Mouse Embryonic Stem Cell–Derived Retinal Ganglion Cells Integrate and Form Synapses in a Retinal Ganglion Cell-Depleted Mouse Model

Metal Oxide Engineered Nanomaterials Modulate Rabbit Corneal Fibroblast to Myofibroblast Transformation

Region of Interest Densitometry Analysis of Descemet Membrane Endothelial Keratoplasty Dehiscence on Anterior Segment Optical Coherence Tomography

Oxidative Stress Resistance 1 Gene Therapy Retards Neurodegeneration in the rd1 Mutant Mouse Model of Retinopathy

Aqueous Cytokine Levels Are Associated With Progression of Peripheral Anterior Synechiae After Descemet Stripping Automated Endothelial Keratoplasty

In Vivo Subretinal ARPE-19 Cell Tracking Using Indocyanine Green Contrast-Enhanced Multimodality Photoacoustic Microscopy, Optical Coherence Tomography, and Fluorescence Imaging for Regenerative Medicine

Transitioning into GMP-Compliance: Alternative Methods for Producing Retinal Organoids for Transplantation

Preclinical Evaluation of the Safety and Efficacy of Cryopreserved Bone Marrow Mesenchymal Stromal Cells for Corneal Repair

The NEI Audacious Goals Initiative: Advancing the Frontier of Regenerative Medicine

Retinal Protection by Sustained Nanoparticle Delivery of Oncostatin M and Ciliary Neurotrophic Factor Into Rodent Models of Retinal Degeneration

Optic Nerve Engraftment of Neural Stem Cells

Transcriptomic Profiling of Control and Thyroid-Associated Orbitopathy (TAO) Orbital Fat and TAO Orbital Fibroblasts Undergoing Adipogenesis

Effect of Vitamin D3 on Regulating Human Tenon's Fibroblasts Activity

Ex Vivo–Induced Bone Marrow-Derived Myeloid Suppressor Cells Prevent Corneal Allograft Rejection in Mice

Longitudinal Evaluation of Hyper-Reflective Foci in the Retina Following Subretinal Delivery of Adeno-Associated Virus in Non-Human Primates

Effect of CPAP Therapy on 24-Hour Intraocular Pressure-Related Pattern From Contact Lens Sensors in Obstructive Sleep Apnea Syndrome

Omidenepag, a Selective, Prostanoid EP2 Agonist, Does Not Suppress Adipogenesis in 3D Organoids of Human Orbital Fibroblasts

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