Cornea

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Cornea April 2025

Expression Distribution of Keratins in Normal and Pathological Corneas and the Regulatory Role of Krt17 on Limbal Stem Cells

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Min Wang; Rong Chen; Yao Wang; Ya Li; Qingjun Zhou; Rui Cao; Yizhou Li; Hongqi Ge; Xiaolei Wang; Lingling Yang
TAGS: cornea, keratins, limbal stem cells, proteins, stress, epithelium, mice, corneal epithelium, rna, messenger, rna-seq
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):55. https://doi.org/10.1167/iovs.66.4.55

Includes: Supplemental Content

Cornea April 2025

Pax6 Directly Regulates the Raver2/sFlt-1 Expression in Corneal Epithelial Cells to Maintain the Cornea's Avascular Privilege

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Haiqi Xiao; Li Hu; Xiongshi Lin; Linchang Liu; Xing Dong; Liting Yang; Ying Liu; Zhichong Wang; Ying Tian; Shuangyong Wang
TAGS: pax6 transcription factor, soluble fms-like tyrosine kinase 1
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):52. https://doi.org/10.1167/iovs.66.4.52

Includes: Supplemental Content

Cornea & External Disease April 2025

A Novel Approach to Fabricate Early Keratoconus Phantom Models

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Hui Tong; Mingjue Wu; Jianqiang Han; Lin Li; Haixia Zhang
TAGS: cornea, keratoconus, phantoms, imaging, silicones
Trans. Vis. Sci. Tech.. 2025; 14(4):18. https://doi.org/10.1167/tvst.14.4.18

Cornea & External Disease April 2025

A Tear-Based Approach for Rapid Identification of Bacterial Pathogens in Corneal Ulcers Using Nanopore Sequencing

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Mark Dibbs; Mitchelle Matesva; Despoina Theotoka; Christina Jayaraj; Beruk Metiku; Patrick Demkowicz; Jacob S. Heng; Yvonne Wang; Christine Y. Bakhoum; Jessica Chow; Mathieu F. Bakhoum
TAGS: bacteria, corneal ulcer, nanopore sequencing, pathogenic organism, ulcer, eye, cornea
Trans. Vis. Sci. Tech.. 2025; 14(4):19. https://doi.org/10.1167/tvst.14.4.19

Includes: Supplemental Content

Cornea April 2025

Quantitative Stain-Free Conjunctival Collagen Imaging in Cicatrizing Conjunctivitis Using Second Harmonic Generation-Two Photon Excitation Technology

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Ralene Sim; Andri K. Riau; Nuur Shahinda Humaira binte Halim; Jodhbir S. Mehta; Hon Shing Ong
TAGS: collagen, conjunctiva, conjunctivitis, diagnostic imaging, excitation, harmonics, photons, technology, cicatrix
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):49. https://doi.org/10.1167/iovs.66.4.49

Includes: Supplemental Content

Cornea April 2025

Quantitative Changes in the Proteome of Chronically Inflamed Lacrimal Glands From a Sjögren's Disease Animal Model

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Danny Toribio; Junji Morokuma; Dante Pellino; Markus Hardt; Driss Zoukhri
TAGS: animal model, langer-giedion syndrome, peptides, proteins, proteome, sjogren's syndrome, liquid chromatography-mass spectrometry, lacrimal gland, fluorescent antibody technique, mice
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):44. https://doi.org/10.1167/iovs.66.4.44

Includes: Supplemental Content

Anatomy and Pathology/Oncology April 2025

Corneal Sensory Nerve Injury Disrupts Lacrimal Gland Function by Altering Circadian Rhythms in Mice

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Senmao Li; Jingbin Xie; Jiayan Xiang; Ruyu Yan; Jiangman Liu; Qiwei Fan; Liyuan Lu; Jiaxin Wu; Jun Liu; Yunxia Xue; Ting Fu; Zhijie Li
TAGS: cornea, lacrimal gland, nerve injuries, neurons, rhythm, circadian rhythms, nerve supply, mice, wounds and injuries, sensory nerves
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):40. https://doi.org/10.1167/iovs.66.4.40

Includes: Supplemental Content

Cornea April 2025

Antigen Presentation by Extracellular Vesicles in the Acute Phase of Corneal Transplantation

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Toshiki Shimizu; Takahiko Hayashi; Junki Kurita; Kentaro Yuda; Nobuhisa Mizuki; Satoru Yamagami
TAGS: antigen processing and presentation, extracellular vesicles, keratoplasty, tissue transplants, cornea
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):38. https://doi.org/10.1167/iovs.66.4.38

Includes: Supplemental Content

Cornea April 2025

Proliferator–Activated Receptor Alpha Inhibits Abnormal Extracellular Matrix Accumulation and Maintains Energy Metabolism in Late-Onset Fuchs Endothelial Corneal Dystrophy

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Xiaoqi Li; Anqi Liu; Yannan Zhou; Haolan Qi; Junyi Wang; Mingxiong Chen; Tunan Sun; Jie Wu; Yifei Huang; Liqiang Wang
TAGS: cornea, endothelium, mice, ppar alpha, chronic exertional compartment syndrome, fenofibrate, hereditary corneal dystrophy
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):36. https://doi.org/10.1167/iovs.66.4.36

Includes: Supplemental Content

Visual Neuroscience April 2025

Depth-Related Visuomotor Performance in Keratoconus and Its Relationship to Stereopsis

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Preetirupa Devi; Christa M. Bhengra; Deepak Kumar; Rashmi Deshmukh; Pravin K. Vaddavalli; Joshua A. Solomon; Christopher W. Tyler; Shrikant R. Bharadwaj
TAGS: depth perception, keratoconus, task performance and analysis, vision, contact lenses, muscle rigidity, image quality
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):31. https://doi.org/10.1167/iovs.66.4.31

Cornea April 2025

KGF-2 Alleviates Dry Eye Disease by Regulating the HMGB1/TLR4 Pathway

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Yuzhou Wang; Zhiqiang Xu; Linzhi Wei; Yang Lu; Yizhou Shi; Shiyu Wen; Xiujuan Lv; Kaiyan Huang; Fan Lu; Jia Qu; Liang Hu
TAGS: hmgb1 protein, mice, toll-like receptor 4, inflammation, dry eye syndromes, cornea
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):28. https://doi.org/10.1167/iovs.66.4.28

Includes: Supplemental Content

Biochemistry and Molecular Biology April 2025

Treatment of Pathological Lymphangiogenesis via Circular RNA-Mediated Cholesterol Metabolism Remodeling

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Shuting Lu; Qian Liu; Fan Ye; Ziran Zhang; Lianjun Shi; Xiumiao Li; Wan Mu; Qin Jiang; Biao Yan
TAGS: cholesterol metabolism, lymphangiogenesis, lymphatic vessels, rna, cornea, sutures, circular rna, mice
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):26. https://doi.org/10.1167/iovs.66.4.26

Includes: Supplemental Content

Cornea & External Disease April 2025

An Improved Monte Carlo Method for Quantitative Analysis of Transparency Degradation Caused by Corneal Edema

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Shuaiyi Li; Yiping Liu; Bao Yang; Sulei Lv; Xiulan Zou; Liqun Tang; Licheng Zhou; Zhenyu Jiang; Zejia Liu
TAGS: catabolism, cornea, corneal edema, monte carlo method, transparency, fibril
Trans. Vis. Sci. Tech.. 2025; 14(4):15. https://doi.org/10.1167/tvst.14.4.15

Cornea & External Disease April 2025

Causal Relationship Between Common Allergic Diseases and Keratoconus: A Two-Sample Mendelian Randomization Study

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Xiru Yang; Xinyao Yu; Shan Gao; Pinghui Wei; Guoge Han
TAGS: extrinsic asthma, hypersensitivity, keratoconus, mendelian randomization analysis, atopic dermatitis, urticaria
Trans. Vis. Sci. Tech.. 2025; 14(4):14. https://doi.org/10.1167/tvst.14.4.14

Cornea & External Disease April 2025

Hyperbaric Oxygenation Increases Available Oxygen and Resistance to Enzymatic Digestion in Accelerated Corneal Collagen Crosslinking

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Johannes Menzel-Severing; Theresa Streit; Jule Schmiedel; Sven Dreyer; Theo G. Seiler; Joana Witt; Gerd Geerling
TAGS: corneal collagen cross-linking, digestion, hyperbaric oxygenation, oxygen, cornea
Trans. Vis. Sci. Tech.. 2025; 14(4):13. https://doi.org/10.1167/tvst.14.4.13

Cornea April 2025

Iron-Sulfur Clusters and Iron Responsive Element Binding Proteins Mediate Iron Accumulation in Corneal Endothelial Cells in Fuchs Dystrophy

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Emma M. Hartness; Hanna Shevalye; Jessica M. Skeie; Timothy Eggleston; Matthew G. Field; Gregory A. Schmidt; Pornpoj Phruttiwanichakun; Aliasger K. Salem; Mark A. Greiner
TAGS: carrier proteins, chronic exertional compartment syndrome, cornea, endothelial cells, genes, iron, proteins, sulfur, ferroptosis, mice
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):23. https://doi.org/10.1167/iovs.66.4.23

Includes: Supplemental Content

Cornea April 2025

Heterozygous Tcf4 Deficiency Mitigates Fuchs Endothelial Corneal Dystrophy Progression in a Mouse Model

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Suguru Ito; Yuki Oyama; Taichi Yuasa; Koki Amano; Kotaro Onishi; Ayaka Izumi; Albert S. Jun; Masahito Ikawa; Noriko Koizumi; Naoki Okumura
TAGS: cornea, endothelium, hereditary corneal dystrophy, heterozygote, mice, endothelial cells, genes
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):19. https://doi.org/10.1167/iovs.66.4.19

Includes: Supplemental Content

Cornea April 2025

CD4 + CD25 − T-Cell–Secreted IFN-γ Promotes Corneal Nerve Degeneration in Diabetic Mice

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Yujing Lin; Lingling Yang; Ya Li; Shengqian Dou; Zhenzhen Zhang; Qingjun Zhou
TAGS: antigens, cd25, cornea, diabetes mellitus, mice, nerve degeneration, t-lymphocytes, neuropathy, neuronal outgrowth, neurons
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):15. https://doi.org/10.1167/iovs.66.4.15

Includes: Supplemental Content

Cornea & External Disease April 2025

Characterization of Directional Reflectance in Corneal Tissue: A Comprehensive Optical Coherence Tomography Analysis

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Jad F. Assaf; Jiachi Hong; Yan Li; David Huang
TAGS: cornea, incidence, optical coherence tomography, body tissue
Trans. Vis. Sci. Tech.. 2025; 14(4):7. https://doi.org/10.1167/tvst.14.4.7

Cornea April 2025

Histopathological Evaluation of Corneal Tissues in Microsporidia Stromal Keratitis

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Sohini Mandal; Soumya Sucharita; Vishwajeet Deshmukh; Smruti Rekha Priyadarshini; Srikant Kumar Sahu; Sujata Das
TAGS: body tissue, cornea, histopathology tests, microsporidia, stromal keratitis, inflammation, plant spores, reproduction spores, kidney, sponge
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):9. https://doi.org/10.1167/iovs.66.4.9

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Expression Distribution of Keratins in Normal and Pathological Corneas and the Regulatory Role of Krt17 on Limbal Stem Cells

Pax6 Directly Regulates the Raver2/sFlt-1 Expression in Corneal Epithelial Cells to Maintain the Cornea's Avascular Privilege

A Novel Approach to Fabricate Early Keratoconus Phantom Models

A Tear-Based Approach for Rapid Identification of Bacterial Pathogens in Corneal Ulcers Using Nanopore Sequencing

Quantitative Stain-Free Conjunctival Collagen Imaging in Cicatrizing Conjunctivitis Using Second Harmonic Generation-Two Photon Excitation Technology

Quantitative Changes in the Proteome of Chronically Inflamed Lacrimal Glands From a Sjögren's Disease Animal Model

Corneal Sensory Nerve Injury Disrupts Lacrimal Gland Function by Altering Circadian Rhythms in Mice

Antigen Presentation by Extracellular Vesicles in the Acute Phase of Corneal Transplantation

Proliferator–Activated Receptor Alpha Inhibits Abnormal Extracellular Matrix Accumulation and Maintains Energy Metabolism in Late-Onset Fuchs Endothelial Corneal Dystrophy

Depth-Related Visuomotor Performance in Keratoconus and Its Relationship to Stereopsis

KGF-2 Alleviates Dry Eye Disease by Regulating the HMGB1/TLR4 Pathway

Treatment of Pathological Lymphangiogenesis via Circular RNA-Mediated Cholesterol Metabolism Remodeling

An Improved Monte Carlo Method for Quantitative Analysis of Transparency Degradation Caused by Corneal Edema

Causal Relationship Between Common Allergic Diseases and Keratoconus: A Two-Sample Mendelian Randomization Study

Hyperbaric Oxygenation Increases Available Oxygen and Resistance to Enzymatic Digestion in Accelerated Corneal Collagen Crosslinking

Iron-Sulfur Clusters and Iron Responsive Element Binding Proteins Mediate Iron Accumulation in Corneal Endothelial Cells in Fuchs Dystrophy

Heterozygous Tcf4 Deficiency Mitigates Fuchs Endothelial Corneal Dystrophy Progression in a Mouse Model

CD4 + CD25 − T-Cell–Secreted IFN-γ Promotes Corneal Nerve Degeneration in Diabetic Mice

Characterization of Directional Reflectance in Corneal Tissue: A Comprehensive Optical Coherence Tomography Analysis

Histopathological Evaluation of Corneal Tissues in Microsporidia Stromal Keratitis

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