Eye Anatomy and Disorders

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Genetics April 2025

Detailed Clinical, Ophthalmic, and Genetic Characterization of MYO7A -Associated Usher Syndrome

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Juan C. Romo-Aguas; Thales A. C. de Guimarães; Angelos Kalitzeos; Nancy Aychoua; Chrysanthi Tsika; Anthony G. Robson; Yu Fujinami-Yokokawa; Kaoru Fujinami; Omar A. Mahroo; Andrew R. Webster; Michel Michaelides
TAGS: eye, follow-up, genetics, natural history, usher syndrome, cohort studies, phenotype, retinal imaging, diagnostic imaging
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):60. https://doi.org/10.1167/iovs.66.4.60

Includes: Supplemental Content

Retina April 2025

Use of SGLT2 Inhibitors Versus DPP-4 Inhibitors and Age-Related Macular Degeneration in Patients WithType 2 Diabetes: A Multinational Cohort Study

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Ssu-Yu Pan; Chien-Hsiang Weng; Shang-Feng Tsai; Hui-Ju Lin; Jun-Fu Lin; Ching-Heng Lin; I-Jong Wang; Chien-Chih Chou
TAGS: age-related macular degeneration, diabetes mellitus, type 2, dipeptidyl-peptidase iv inhibitors, sodium-glucose transporter 2 inhibitors, diabetes mellitus, cohort studies
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):58. https://doi.org/10.1167/iovs.66.4.58

Includes: Supplemental Content

Retina April 2025

Assessment of Ocular Magnification in Relation to Biometric Parameters and Measurement Techniques: A Prospective Study

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Serhat Ermiş; Ece Özal; Emrullah Şimşek; Özlem Taştan; Murat Karapapak
TAGS: biometry, magnification, prospective studies, fovea centralis, eye
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):57. https://doi.org/10.1167/iovs.66.4.57

Retina April 2025

Fluorescence Lifetime Imaging Ophthalmoscopy, Vision, and Chorioretinal Asymmetries in Aging and Age-Related Macular Degeneration: ALSTAR2

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Lukas Goerdt; Mark E. Clark; Tracy N. Thomas; Liyan Gao; Gerald McGwin, Jr.; Martin Hammer; Jason N. Crosson; Kenneth R. Sloan; Cynthia Owsley; Christine A. Curcio
TAGS: age-related macular degeneration, aging, diagnostic imaging, eye, fluorescence, ophthalmoscopy, vision, cohort studies
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):56. https://doi.org/10.1167/iovs.66.4.56

Includes: Supplemental Content

Cornea April 2025

Expression Distribution of Keratins in Normal and Pathological Corneas and the Regulatory Role of Krt17 on Limbal Stem Cells

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Min Wang; Rong Chen; Yao Wang; Ya Li; Qingjun Zhou; Rui Cao; Yizhou Li; Hongqi Ge; Xiaolei Wang; Lingling Yang
TAGS: cornea, keratins, limbal stem cells, proteins, stress, epithelium, mice, corneal epithelium, rna, messenger, rna-seq
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):55. https://doi.org/10.1167/iovs.66.4.55

Includes: Supplemental Content

Clinical and Epidemiologic Research April 2025

Life's Essential 8, Genetic Susceptibility, and the Risk of Age-Related Macular Degeneration: A Prospective Cohort Study

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Wenxu Wang; Rui Ren; Yue Liu; Xingyue Ye; Ru Zhang; Linze Xi; Liying Wang; Yao Zhang; Yi Zhang; Difei Wang
TAGS: age-related macular degeneration, genetic predisposition to disease, genetics, health, polygenic risk score, prospective studies
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):54. https://doi.org/10.1167/iovs.66.4.54

Includes: Supplemental Content

Retina April 2025

Characterizing the Field of Fluidic Effect Around Vitrectomy Probes Using Particle Image Velocimetry

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Dhamotharan Veerasamy; Daria Vedeniapina; Michael Wilkes; David H. Steel; Richard D. Whalley
TAGS: fluid flow, particle image velocimetry, pulmonary aspiration, velocity, vitrectomy
Trans. Vis. Sci. Tech.. 2025; 14(4):20. https://doi.org/10.1167/tvst.14.4.20

Cornea April 2025

Pax6 Directly Regulates the Raver2/sFlt-1 Expression in Corneal Epithelial Cells to Maintain the Cornea's Avascular Privilege

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Haiqi Xiao; Li Hu; Xiongshi Lin; Linchang Liu; Xing Dong; Liting Yang; Ying Liu; Zhichong Wang; Ying Tian; Shuangyong Wang
TAGS: pax6 transcription factor, soluble fms-like tyrosine kinase 1
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):52. https://doi.org/10.1167/iovs.66.4.52

Includes: Supplemental Content

Biochemistry and Molecular Biology April 2025

NMN Supplementation Inhibits Endothelial Cell ROS-Mediated Src/Pi3k/Akt Signaling Pathway to Protect High-Altitude Blood-Retinal Barrier

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Siyuan Liu; Ning Du; Keke Ge; Jiayue Hu; Wenfang Zhang
TAGS: 1-phosphatidylinositol 3-kinase, endothelial cells, high altitude, hypoxia, cadherins, akt signaling pathway, mice, fluorescent antibody technique, evans blue stain, blood-retinal barrier
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):51. https://doi.org/10.1167/iovs.66.4.51

Includes: Supplemental Content

Cornea & External Disease April 2025

A Novel Approach to Fabricate Early Keratoconus Phantom Models

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Hui Tong; Mingjue Wu; Jianqiang Han; Lin Li; Haixia Zhang
TAGS: cornea, keratoconus, phantoms, imaging, silicones
Trans. Vis. Sci. Tech.. 2025; 14(4):18. https://doi.org/10.1167/tvst.14.4.18

Cornea & External Disease April 2025

A Tear-Based Approach for Rapid Identification of Bacterial Pathogens in Corneal Ulcers Using Nanopore Sequencing

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Mark Dibbs; Mitchelle Matesva; Despoina Theotoka; Christina Jayaraj; Beruk Metiku; Patrick Demkowicz; Jacob S. Heng; Yvonne Wang; Christine Y. Bakhoum; Jessica Chow; Mathieu F. Bakhoum
TAGS: bacteria, corneal ulcer, nanopore sequencing, pathogenic organism, ulcer, eye, cornea
Trans. Vis. Sci. Tech.. 2025; 14(4):19. https://doi.org/10.1167/tvst.14.4.19

Includes: Supplemental Content

Immunology and Microbiology April 2025

Application of Metagenomic Long-Read Sequencing for the Diagnosis of Herpetic Uveitis

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Yoshito Koyanagi; Ai Fujita Sajiki; Kenya Yuki; Hiroaki Ushida; Kenichi Kawano; Kosuke Fujita; Hideyuki Shimizu; Daishi Okuda; Mitsuki Kosaka; Kazuhisa Yamada; Ayana Suzumura; Shu Kachi; Hiroki Kaneko; Hiroyuki Komatsu; Yoshihiko Usui; Hiroshi Goto; Koji M. Nishiguchi
TAGS: reading (activity), uveitis, metagenomic sequencing, nanopores, fluid flow
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):50. https://doi.org/10.1167/iovs.66.4.50

Includes: Supplemental Content

Cornea April 2025

Quantitative Stain-Free Conjunctival Collagen Imaging in Cicatrizing Conjunctivitis Using Second Harmonic Generation-Two Photon Excitation Technology

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Ralene Sim; Andri K. Riau; Nuur Shahinda Humaira binte Halim; Jodhbir S. Mehta; Hon Shing Ong
TAGS: collagen, conjunctiva, conjunctivitis, diagnostic imaging, excitation, harmonics, photons, technology, cicatrix
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):49. https://doi.org/10.1167/iovs.66.4.49

Includes: Supplemental Content

Glaucoma April 2025

Targeted Neuroprotection of Retinal Ganglion Cells Via AAV2-hSyn-NGF Gene Therapy in Glaucoma Models

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Xinlei Zhu; Benxiang Qi; Zhongmei Ren; Lin Cong; Xiaojing Pan; Qingjun Zhou; Bi Ning Zhang; Lixin Xie
TAGS: glaucoma, injections, gene therapy, neuroprotection, retinal ganglion cells, intravitreal injections
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):48. https://doi.org/10.1167/iovs.66.4.48

Includes: Supplemental Content

Clinical and Epidemiologic Research April 2025

Biological Age Acceleration, Genetic Susceptibility, and Incident Glaucoma Risk

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Wei-Qi Song; Wen-Fang Zhong; Zhi-Hao Li; Dan Liu; Jiao-Jiao Ren; Dong Shen; Jian Gao; Pei-Liang Chen; Jin Yang; Xiao-Meng Wang; Fang-Fei You; Chuan Li; Huan Chen; Jia-Hao Xie; Chen Mao
TAGS: glaucoma, genetic predisposition to disease
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):47. https://doi.org/10.1167/iovs.66.4.47

Includes: Supplemental Content

Glaucoma April 2025

Vitamin K1 Alleviates Retinal Inflammation Following Acute Ocular Hypertension by Modulating Microglial Ferroptosis

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Xi Chen; Yan Rong; Yuxian Jiang; Qiuxiang Zhang; Sifei Xiang; Zhiqi Chen; Wei Chen; Hong Zhang; Chaohua Deng; Junming Wang
TAGS: retinitis, vitamin k 1, wounds and injuries, ocular hypertension, ferroptosis
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):46. https://doi.org/10.1167/iovs.66.4.46

Cornea April 2025

Quantitative Changes in the Proteome of Chronically Inflamed Lacrimal Glands From a Sjögren's Disease Animal Model

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Danny Toribio; Junji Morokuma; Dante Pellino; Markus Hardt; Driss Zoukhri
TAGS: animal model, langer-giedion syndrome, peptides, proteins, proteome, sjogren's syndrome, liquid chromatography-mass spectrometry, lacrimal gland, fluorescent antibody technique, mice
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):44. https://doi.org/10.1167/iovs.66.4.44

Includes: Supplemental Content

Glaucoma April 2025

Association Between Cup-to-Disc Ratio and Structural and Functional Damage Parameters in Glaucoma: Insights From Multiparametric Modeling

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Aliah McCalla; Mengyu Wang; Mohammad Eslami; Saber Kazeminasab; Yan Luo; Hannah Rana; Sajib Saha; Min Shi; Yu Tian; Nazlee Zebardast; Tobias Elze
TAGS: glaucoma, clinicians, optic disk
Trans. Vis. Sci. Tech.. 2025; 14(4):17. https://doi.org/10.1167/tvst.14.4.17

Includes: Supplemental Content

Article April 2025

Visual factors that determine sensory uncertainty in rapid interceptive hand movements

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Abibat A. Akande; Philipp Kreyenmeier; Miriam Spering
TAGS: eye, motion, movement of hand, saccades, eye-hand coordination
Journal of Vision. 2025; 25(4):8. https://doi.org/10.1167/jov.25.4.8

Article April 2025

No robust evidence for an effect of head-movement propensity on central bias in head-constrained scene viewing, despite an effect on fixation duration

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Patricia R. Mueller; Sabine Grimm; Wolfgang Einhäuser
TAGS: head movements, gaze, electronic medical records, eye
Journal of Vision. 2025; 25(4):10. https://doi.org/10.1167/jov.25.4.10

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Detailed Clinical, Ophthalmic, and Genetic Characterization of MYO7A -Associated Usher Syndrome

Use of SGLT2 Inhibitors Versus DPP-4 Inhibitors and Age-Related Macular Degeneration in Patients WithType 2 Diabetes: A Multinational Cohort Study

Assessment of Ocular Magnification in Relation to Biometric Parameters and Measurement Techniques: A Prospective Study

Fluorescence Lifetime Imaging Ophthalmoscopy, Vision, and Chorioretinal Asymmetries in Aging and Age-Related Macular Degeneration: ALSTAR2

Expression Distribution of Keratins in Normal and Pathological Corneas and the Regulatory Role of Krt17 on Limbal Stem Cells

Life's Essential 8, Genetic Susceptibility, and the Risk of Age-Related Macular Degeneration: A Prospective Cohort Study

Characterizing the Field of Fluidic Effect Around Vitrectomy Probes Using Particle Image Velocimetry

Pax6 Directly Regulates the Raver2/sFlt-1 Expression in Corneal Epithelial Cells to Maintain the Cornea's Avascular Privilege

NMN Supplementation Inhibits Endothelial Cell ROS-Mediated Src/Pi3k/Akt Signaling Pathway to Protect High-Altitude Blood-Retinal Barrier

A Novel Approach to Fabricate Early Keratoconus Phantom Models

A Tear-Based Approach for Rapid Identification of Bacterial Pathogens in Corneal Ulcers Using Nanopore Sequencing

Application of Metagenomic Long-Read Sequencing for the Diagnosis of Herpetic Uveitis

Quantitative Stain-Free Conjunctival Collagen Imaging in Cicatrizing Conjunctivitis Using Second Harmonic Generation-Two Photon Excitation Technology

Targeted Neuroprotection of Retinal Ganglion Cells Via AAV2-hSyn-NGF Gene Therapy in Glaucoma Models

Biological Age Acceleration, Genetic Susceptibility, and Incident Glaucoma Risk

Vitamin K1 Alleviates Retinal Inflammation Following Acute Ocular Hypertension by Modulating Microglial Ferroptosis

Quantitative Changes in the Proteome of Chronically Inflamed Lacrimal Glands From a Sjögren's Disease Animal Model

Association Between Cup-to-Disc Ratio and Structural and Functional Damage Parameters in Glaucoma: Insights From Multiparametric Modeling

Visual factors that determine sensory uncertainty in rapid interceptive hand movements

No robust evidence for an effect of head-movement propensity on central bias in head-constrained scene viewing, despite an effect on fixation duration

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