Pharmacology

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Retina November 2024

Preservation of Murine Whole Eyes With Supplemented UW Cold Storage Solution: Anatomical Considerations

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Nicole A. Muench; Heather M. Schmitt; Cassandra L. Schlamp; An-Jey A. Su; Kia Washington; Robert W. Nickells
TAGS: cryopreservation, eye, mice
Trans. Vis. Sci. Tech.. 2024; 13(11):24. https://doi.org/10.1167/tvst.13.11.24

Includes: Supplemental Content

Biochemistry and Molecular Biology November 2024

Tapinarof, an Aryl Hydrocarbon Receptor Ligand, Mitigates Fibroblast Activation in Thyroid Eye Disease: Implications for Novel Therapy

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Charkira C. Patrick; Elisa Roztocil; Farha Husain; Steven E. Feldon; Collynn F. Woeller
TAGS: aryl hydrocarbon receptor, fibroblasts, graves' ophthalmopathy, ligands, signal transduction, tapinarof, platelet-derived growth factor, thymidylate synthase, proto-oncogene proteins c-akt
Invest. Ophthalmol. Vis. Sci.. 2024; 65(13):40. https://doi.org/10.1167/iovs.65.13.40

Includes: Supplemental Content

Cornea & External Disease November 2024

Exploring New Links Among Keratoconus, Hormonal Factors, and Medications: Insights From a Case–Control Study Utilizing the All of Us Database

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Carol Beatty; Amy Estes; Hongyan Xu; Yutao Liu
TAGS: estrogen, keratoconus, pharmaceutical preparations, risk factors, obesity, medical history, dry eye syndromes
Trans. Vis. Sci. Tech.. 2024; 13(11):18. https://doi.org/10.1167/tvst.13.11.18

Cornea November 2024

Deletion of Fgfr2 in Ductal Basal Epithelium With Tamoxifen Induces Obstructive Meibomian Gland Dysfunction

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Xiaowei Yang; Xingwu Zhong; Haotian Lin; Andrew J.W. Huang; Lixing W. Reneker
TAGS: atrophy, epithelium, fgfr2 gene, meibomian gland dysfunction, mice, tamoxifen
Invest. Ophthalmol. Vis. Sci.. 2024; 65(13):36. https://doi.org/10.1167/iovs.65.13.36

Includes: Supplemental Content

Cornea November 2024

Restoration of Corneal Stiffness in Rabbits Following Withdrawal of Travoprost

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XiaoBo Zheng; Chong Wang; YiWen Fan; YuXin Hong; Han Bao; ErChi Zhang; Yi Jin; Peng Yang; LingQiao Li; JunJie Wang; ShiHao Chen; Ahmed Elsheikh; FangJun Bao
TAGS: cornea, oryctolagus cuniculus, travoprost, cardiac ct, multiple wake test, eye
Invest. Ophthalmol. Vis. Sci.. 2024; 65(13):35. https://doi.org/10.1167/iovs.65.13.35

Retina November 2024

Potential Drug Targets for Diabetic Retinopathy Identified Through Mendelian Randomization Analysis

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Huan Liu; Feiyan Wang; Ziqing Hu; Jing Wei
TAGS: diabetic retinopathy, drug delivery systems, mendelian randomization analysis, plasma proteins, proteins
Trans. Vis. Sci. Tech.. 2024; 13(11):17. https://doi.org/10.1167/tvst.13.11.17

Includes: Supplemental Content

Retina November 2024

Ocular Pharmacokinetics of Faricimab Following Intravitreal Administration in Patients With Retinal Disease

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Cheikh Diack; Leonid Gibiansky; Felix Jaminion; Ekaterina Gibiansky; Jacques Gaudreault; Katrijn Bogman; Valerie Cosson
TAGS: faricimab, intravitreal injections, retinal diseases, pharmacokinetics, hypertension, plasma
Trans. Vis. Sci. Tech.. 2024; 13(11):14. https://doi.org/10.1167/tvst.13.11.14

Includes: Supplemental Content

Retina November 2024

Ocular Pharmacodynamics of Intravitreal Faricimab in Patients With Neovascular Age-Related Macular Degeneration or Diabetic Macular Edema

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Cheikh Diack; Robert L. Avery; Chui Ming Gemmy Cheung; Karl G. Csaky; Leonid Gibiansky; Felix Jaminion; Ekaterina Gibiansky; Denise Sickert; Ivo Stoilov; Valerie Cosson; Katrijn Bogman
TAGS: diabetic macular edema, exudative age-related macular degeneration, faricimab, hypertension, vascular endothelial growth factor a, pharmacodynamics
Trans. Vis. Sci. Tech.. 2024; 13(11):13. https://doi.org/10.1167/tvst.13.11.13

Includes: Supplemental Content

Glaucoma November 2024

Ocular Tissue Distribution of Omidenepag Isopropyl in Rabbits and Cynomolgus Monkeys

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Kenzo Yamamura; Hidetoshi Mano; Masahiro Fuwa; Ryo Iwamura; Noriko Odani-Kawabata
TAGS: cercopithecidae, drug or chemical tissue distribution, macaca fascicularis, omidenepag, oryctolagus cuniculus, radioactivity, cornea, eye, aqueous humor, administration, topical
Trans. Vis. Sci. Tech.. 2024; 13(11):6. https://doi.org/10.1167/tvst.13.11.6

Retinal Cell Biology November 2024

Cysteine Leukotriene Receptor Antagonist-Montelukast Effects on Diabetic Retinal Microvascular Endothelial Cells Curtail Autophagy

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Ahmed M. Awad; Amritha T. M. Seetharaman; Mohammad Shahadat Hossain; Sally L. Elshaer; Rania R. Abdelaziz; Manar A. Nader; Rajashekhar Gangaraju
TAGS: autophagy, diabetes mellitus, endothelial cells, endothelium, hyperglycemia, montelukast, tumor necrosis factors, antagonists, leukotriene receptor, inflammation
Invest. Ophthalmol. Vis. Sci.. 2024; 65(13):15. https://doi.org/10.1167/iovs.65.13.15

Includes: Supplemental Content

Retina October 2024

A First-Passage Model of Intravitreal Drug Delivery and Residence Time—Influence of Ocular Geometry, Individual Variability, and Injection Location

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Patricia Lamirande; Eamonn A. Gaffney; Michael Gertz; Philip K. Maini; Jessica R. Crawshaw; Antonello Caruso
TAGS: drug delivery systems, eye, injections, vitreous body, immunoglobulin g, molecule, drug elimination routes, drug excretion
Invest. Ophthalmol. Vis. Sci.. 2024; 65(12):21. https://doi.org/10.1167/iovs.65.12.21

Includes: Supplemental Content

Retina October 2024

Fetuin-B Interacts With Insulin Receptor-β and Promotes Insulin Resistance in Retina Cells

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Wenyi Zhang; Xin Wang; Shuwei Tian; Jianming Wang; Aiyi Zhou
TAGS: insulin, insulin resistance, retina, alpha-fetoproteins, glucose
Invest. Ophthalmol. Vis. Sci.. 2024; 65(12):16. https://doi.org/10.1167/iovs.65.12.16

Includes: Supplemental Content

Physiology and Pharmacology October 2024

Comprehensive Pharmacokinetic Evaluation of High Melanin Binder Levofloxacin in Rabbits Shows Potential of Topical Eye Drops for Posterior Segment Treatment

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Sina Bahrpeyma; Paulina Jakubiak; Rubén Alvarez-Sánchez; Antonello Caruso; Monika Leuthardt; Claudia Senn; Eva M. del Amo; Arto Urtti
TAGS: body tissue, drug delivery, targeted, eyedrops, levofloxacin, melanins, oryctolagus cuniculus, albinism, multiple-dose regimen
Invest. Ophthalmol. Vis. Sci.. 2024; 65(12):14. https://doi.org/10.1167/iovs.65.12.14

Includes: Supplemental Content

Glaucoma October 2024

IOP Reduction in Nonhuman Primates by Microneedle Injection of Drug-Free Hydrogel to Expand the Suprachoroidal Space

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Yooree G. Chung; Shan Fan; Vikas Gulati; Hoi-Lam Li; Haiyan Gong; Carol B. Toris; Mark R. Prausnitz; C. Ross Ethier
TAGS: hydrogel, injections, intraocular pressure, eye, hypertension
Trans. Vis. Sci. Tech.. 2024; 13(10):14. https://doi.org/10.1167/tvst.13.10.14

Includes: Supplemental Content

Retina October 2024

Retinal Function in Young Adults Following Topical Application of Levodopa to the Eye

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Faran Sabeti; Kate Thomson; Ted Maddess; Cindy Karouta; Myra Leung; Nicola Anstice; Tina Jong; Regan Ashby
TAGS: eye, levodopa, retina, administration, topical, carbidopa, young adult, perimetry, placebos
Trans. Vis. Sci. Tech.. 2024; 13(10):12. https://doi.org/10.1167/tvst.13.10.12

Includes: Supplemental Content

Neuro-ophthalmology September 2024

Pharmacological Activation and Transgenic Overexpression of SIRT1 Attenuate Traumatic Optic Neuropathy Induced by Blunt Head Impact

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Alex Kwok; Brahim Chaqour; Reas S. Khan; Puya Aravand; Kimberly Dine; Ahmara G. Ross; Kenneth S. Shindler
TAGS: mice, traumatic brain injuries, protein overexpression, optic nerve injuries, attenuation, pharmacology, vision
Trans. Vis. Sci. Tech.. 2024; 13(9):27. https://doi.org/10.1167/tvst.13.9.27

Immunology and Microbiology September 2024

Relationship Between Fluoroquinolone Resistance and Mutations in the Quinolone Resistance-Determining Region in Corynebacterium macginleyi

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Nobuhiro Kato; Masatoshi Haruta; Rikki Arai; Kazunori Sato; Kei Furushima; Kanako Yokomizo; Miki Okuno; Takeshi Yamamoto; Yoshitoshi Ogura; Shigeo Yoshida
TAGS: corynebacterium, fluoroquinolones, mutation, quinolones, resistance genes, conjunctiva
Invest. Ophthalmol. Vis. Sci.. 2024; 65(11):38. https://doi.org/10.1167/iovs.65.11.38

Anatomy and Pathology/Oncology September 2024

Administration of Nicotine Can Inhibit Myopic Growth in Animal Models

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Kate Thomson; Cindy Karouta; Regan Ashby
TAGS: nicotine
Invest. Ophthalmol. Vis. Sci.. 2024; 65(11):29. https://doi.org/10.1167/iovs.65.11.29

Includes: Supplemental Content

Review September 2024

Mathematical Models of Ocular Drug Delivery

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Amir Sadeghi; Astrid Subrizi; Eva M. del Amo; Arto Urtti
TAGS: aqueous humor, body tissue, drug delivery systems, eye, mathematical model, vitreous body, drug concentration, mass or substance concentration per volume, intravitreal injections, molecule
Invest. Ophthalmol. Vis. Sci.. 2024; 65(11):28. https://doi.org/10.1167/iovs.65.11.28

Includes: Supplemental Content

Retina September 2024

Aqueous Humor Cytokine Analysis in Age-Related Macular Degeneration After Switching From Aflibercept to Faricimab

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Takahito Todoroki; Jun Takeuchi; Hikaru Ota; Yuyako Nakano; Ai Fujita Sajiki; Koichi Nakamura; Hiroki Kaneko; Koji M. Nishiguchi
TAGS: aflibercept, age-related macular degeneration, aqueous humor, cytokine, faricimab, vascular endothelial growth factor a
Invest. Ophthalmol. Vis. Sci.. 2024; 65(11):15. https://doi.org/10.1167/iovs.65.11.15

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Preservation of Murine Whole Eyes With Supplemented UW Cold Storage Solution: Anatomical Considerations

Tapinarof, an Aryl Hydrocarbon Receptor Ligand, Mitigates Fibroblast Activation in Thyroid Eye Disease: Implications for Novel Therapy

Exploring New Links Among Keratoconus, Hormonal Factors, and Medications: Insights From a Case–Control Study Utilizing the All of Us Database

Deletion of Fgfr2 in Ductal Basal Epithelium With Tamoxifen Induces Obstructive Meibomian Gland Dysfunction

Restoration of Corneal Stiffness in Rabbits Following Withdrawal of Travoprost

Potential Drug Targets for Diabetic Retinopathy Identified Through Mendelian Randomization Analysis

Ocular Pharmacokinetics of Faricimab Following Intravitreal Administration in Patients With Retinal Disease

Ocular Pharmacodynamics of Intravitreal Faricimab in Patients With Neovascular Age-Related Macular Degeneration or Diabetic Macular Edema

Ocular Tissue Distribution of Omidenepag Isopropyl in Rabbits and Cynomolgus Monkeys

Cysteine Leukotriene Receptor Antagonist-Montelukast Effects on Diabetic Retinal Microvascular Endothelial Cells Curtail Autophagy

A First-Passage Model of Intravitreal Drug Delivery and Residence Time—Influence of Ocular Geometry, Individual Variability, and Injection Location

Fetuin-B Interacts With Insulin Receptor-β and Promotes Insulin Resistance in Retina Cells

Comprehensive Pharmacokinetic Evaluation of High Melanin Binder Levofloxacin in Rabbits Shows Potential of Topical Eye Drops for Posterior Segment Treatment

IOP Reduction in Nonhuman Primates by Microneedle Injection of Drug-Free Hydrogel to Expand the Suprachoroidal Space

Retinal Function in Young Adults Following Topical Application of Levodopa to the Eye

Pharmacological Activation and Transgenic Overexpression of SIRT1 Attenuate Traumatic Optic Neuropathy Induced by Blunt Head Impact

Relationship Between Fluoroquinolone Resistance and Mutations in the Quinolone Resistance-Determining Region in Corynebacterium macginleyi

Administration of Nicotine Can Inhibit Myopic Growth in Animal Models

Mathematical Models of Ocular Drug Delivery

Aqueous Humor Cytokine Analysis in Age-Related Macular Degeneration After Switching From Aflibercept to Faricimab

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